Publikationsdatenbank

Astrocyte structural heterogeneity in the mouse hippocampus (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Viana, João Filipe

Machado, João Luís

Abreu, Daniela Sofia

Veiga, Alexandra

Barsanti, Sara

Tavares, Gabriela

Martins, Manuella

Sardinha, Vanessa Morais

Guerra‐Gomes, Sónia

Domingos, Cátia

Pauletti, Alberto (WE 14)

Wahis, Jérôme

Liu, Chen

Calì, Corrado

Henneberger, Christian

Holt, Matthew G.

Oliveira, João Filipe

Quelle

Glia

Bandzählung: 71

Heftzählung: 7

Seiten: 1667 – 1682

ISSN: 1098-1136

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1002/glia.24362

DOI: 10.1002/glia.24362

Pubmed: 36949723

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Astrocytes are integral components of brain circuits, where they sense, process, and respond to surrounding activity, maintaining homeostasis and regulating synaptic transmission, the sum of which results in behavior modulation. These interactions are possible due to their complex morphology, composed of a tree-like structure of processes to cover defined territories ramifying in a mesh-like system of fine leaflets unresolved by conventional optic microscopy. While recent reports devoted more attention to leaflets and their dynamic interactions with synapses, our knowledge about the tree-like “backbone” structure in physiological conditions is incomplete. Recent transcriptomic studies described astrocyte molecular diversity, suggesting structural heterogeneity in regions such as the hippocampus, which is crucial for cognitive and emotional behaviors. In this study, we carried out the structural analysis of astrocytes across the hippocampal subfields of Cornu Ammonis area 1 (CA1) and dentate gyrus in the dorsoventral axis. We found that astrocytes display heterogeneity across the hippocampal subfields, which is conserved along the dorsoventral axis. We further found that astrocytes appear to contribute in an exocytosis-dependent manner to a signaling loop that maintains the backbone structure. These findings reveal astrocyte heterogeneity in the hippocampus, which appears to follow layer-specific cues and depend on the neuro-glial environment.