Publikationsdatenbank

A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Wolter, Angelique (WE 11)

Bucher, Christian H.

Kurmies, Sebastian

Schreiner, Viktoria

Konietschke, Frank

Hohlbaum, Katharina (WE 11)

Klopfleisch, Robert (WE 12)

Löhning, Max

Thöne-Reineke, Christa (WE 11)

Buttgereit, Frank

Huwyler, Jörg

Jirkof, Paulin

Rapp, Anna E.

Lang, Annemarie

Quelle

Scientific reports

Bandzählung: 13

Heftzählung: 1

Seiten: Article number: 3824

ISSN: 2045-2322

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41598-023-30641-9

DOI: 10.1038/s41598-023-30641-9

Pubmed: 36882427

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Buprenorphine are only available in the USA and have limited duration of action. Recently, a new microparticulate Buprenorphine formulation (BUP-Depot) for sustained release has been developed as a potential future alternative to standard formulations available in Europe. Pharmacokinetics indicate a possible effectiveness for about 72 h. Here, we investigated whether the administration of the BUP-Depot ensures continuous and sufficient analgesia in two mouse fracture models (femoral osteotomy) and could, therefore, serve as a potent alternative to the application of Tramadol via the drinking water. Both protocols were examined for analgesic effectiveness, side effects on experimental readout, and effects on fracture healing outcomes in male and female C57BL/6N mice. The BUP-Depot provided effective analgesia for 72 h, comparable to the effectiveness of Tramadol in the drinking water. Fracture healing outcome was not different between analgesic regimes. The availability of a Buprenorphine depot formulation for rodents in Europe would be a beneficial addition for extended pain relief in mice, thereby increasing animal welfare.