Publikationsdatenbank

Dynamics of extended-spectrum cephalosporin resistance genes in Escherichia coli from Europe and North America (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Zamudio, Roxana

Boerlin, Patrick

Beyrouthy, Racha

Madec, Jean-Yves

Schwarz, Stefan (WE 7)

Mulvey, Michael R.

Zhanel, George G.

Cormier, Ashley

Chalmers, Gabhan

Bonnet, Richard

Haenni, Marisa

Eichhorn, Inga (WE 7)

Kaspar, Heike

Garcia-Fierro, Raquel

Wood, James L. N.

Mather, Alison E.

Quelle

Nature Communications

Bandzählung: 13

Heftzählung: 1

Seiten: Article number: 7490

ISSN: 2041-1723

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41467-022-34970-7

DOI: 10.1038/s41467-022-34970-7

Pubmed: 36509735

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Extended-spectrum cephalosporins (ESCs) are critically important antimicrobial agents for human and veterinary medicine. ESC resistance (ESC-R) genes have spread worldwide through plasmids and clonal expansion, yet the distribution and dynamics of ESC-R genes in different ecological compartments are poorly understood. Here we use whole genome sequence data of Enterobacterales isolates of human and animal origin from Europe and North America and identify contrasting temporal dynamics. AmpC β-lactamases were initially more dominant in North America in humans and farm animals, only later emerging in Europe. In contrast, specific extended-spectrum β-lactamases (ESBLs) were initially common in animals from Europe and later emerged in North America. This study identifies differences in the relative importance of plasmids and clonal expansion across different compartments for the spread of different ESC-R genes. Understanding the mechanisms of transmission will be critical in the design of interventions to reduce the spread of antimicrobial resistance.