Publikationsdatenbank

Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Yang, Lu

Shen, Yingbo

Jiang, Junyao

Wang, Xueyang

Shao, Dongyan

Lam, Margaret M. C.

Holt, Kathryn E.

Shao, Bing

Wu, Congming

Shen, Jianzhong

Walsh, Timothy R.

Schwarz, Stefan (WE 7)

Wang, Yang

Shen, Zhangqi

Quelle

Nature food

Bandzählung: 3

Heftzählung: 3

Seiten: 197 – 205

ISSN: 2662-1355

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s43016-022-00470-6

DOI: 10.1038/s43016-022-00470-6

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Antimicrobial use in livestock production is linked to the emergence and spread of antimicrobial resistance (AMR), but large-scale studies on AMR changes in livestock isolates remain scarce. Here we applied whole-genome sequence analysis to 982 animal-derived Escherichia coli samples collected in China from the 1970s to 2019, finding that the number of AMR genes (ARGs) per isolate doubled—including those conferring resistance to critically important agents for both veterinary (florfenicol and norfloxacin) and human medicine (colistin, cephalosporins and meropenem). Plasmids of incompatibility groups IncC, IncHI2, IncK, IncI and IncX increased distinctly in the past 50 years, acting as highly effective vehicles for ARG spread. Using antimicrobials of the same class, or even unrelated classes, may co-select for mobile genetic elements carrying multiple co-existing ARGs. Prohibiting or strictly curtailing antimicrobial use in livestock is therefore urgently needed to reduce the growing threat from AMR.