Publikationsdatenbank

Tripartite interactions:
how immunity, microbiota and pathogens interact and affect pathogen virulence evolution (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Armitage, Sophie A. O.

Genersch, Elke (WE 7)

McMahon, Dino P.

Rafaluk-Mohr, Charlotte

Rolff, Jens

Quelle

Current opinion in insect science

Bandzählung: 50

Seiten: Artikel 100871

ISSN: 2214-5753

Sprache

Englisch

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/abs/pii/S2214574521001401

DOI: 10.1016/j.cois.2021.12.011

Pubmed: 34999035

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The bipartite interactions between insect hosts and their bacterial gut microbiota, or their bacterial pathogens, are empirically and theoretically well-explored. However, direct, and indirect tripartite interactions will also likely occur inside a host. These interactions will almost certainly affect the trajectory of pathogen virulence evolution, an area that is currently under researched. The interactions within tripartite associations can be competitive, that is, exploitative-competition, interference-competition or apparent-competition. Competitive interactions will be significantly influenced by non-competitive effects, for example, immunopathology, immunosuppression, and microbiota-mediated tolerance. Considering a combination of these interactions and effects, will enable an increased understanding of the evolution of pathogen virulence. This new perspective allows us to identify several novel research questions, which we hope will be a useful framework for future research.