Publikationsdatenbank

Genome reference assembly for bottlenecked southern Australian koalas (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Blanchard, Adam Mark

Emes, Richard David

Greenwood, Alex David (WE 5)

Holmes, Nadine

Loose, Matthew William

McEwen, Gail Katherine

Meers, Joanne

Speight, Natasha

Tarlinton, Rachael Eugenie

Quelle

Genome biology and evolution

Bandzählung: 15

Heftzählung: 1

Seiten: Artikel evac176

ISSN: 1759-6653

Sprache

Englisch

Verweise

URL (Volltext): https://academic.oup.com/gbe/advance-article/doi/10.1093/gbe/evac176/6948355

DOI: 10.1093/gbe/evac176

Pubmed: 36542479

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Koala populations show marked differences in inbreeding levels and in the presence or absence of the endogenous Koala Retrovirus (KoRV). These genetic differences among populations may lead to severe disease impacts threatening koala population viability. In addition, the recent colonization of the koala genome by KoRV provides a unique opportunity to study the process of retroviral adaptation to vertebrate genomes and the impact this has on speciation, genome structure and function. The genome build described here is from an animal from the bottlenecked "Southern" population free of endogenous and exogenous KoRV. It provides a more contiguous genome build than the previous koala reference derived from an animal from a more outbred "Northern" population and is the first koala genome from a KoRV polymerase free animal.