Publikationsdatenbank

Intrinsic differences in liver macrophage polarization are associated with resistance and susceptibility to Ascaris infection (2022)

Art

Poster

Autoren

Elizalde‐Velázquez, Luis E. (WE 6)

Schlosser-Brandenburg, J. (WE 6)

Kühl, A. A.

Hartmann, S. (WE 6)

Kongress

Oxford-Berlin School on Molecular Basis of Inflammatory Diseases - 2022

Berlin, 09. – 10.06.2022

Quelle

Sprache

Englisch

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Ascariasis one of the most prevalent neglected tropical diseases in the world affecting humans and pigs alike shows an overdispersion in their hosts. The reason of this marked variability toward a light or heavy worm burden among human and pig populations is still unknown. We hypothesize that intrinsic genetic differences in protective immune composition leads to different immune responses during the larval hepato-tracheal migration of parasite and account for the overdispersion. In an attempt to identify the cell populations involved we infected two mouse strains mimicking the hepato-tracheal migration of the natural hosts but showing contrasting phenotypes of resistance versus susceptibility to infection. Preliminary data show significant differences in innate and adaptive immune cells phenotype and function locally in liver and lung as well as systemically in response to Ascaris primary infection and give insights into cellular responses leading to early killing of Ascaris larvae.