Publikationsdatenbank

Whip- and pinworm infections elicit contrasting effector and distinct regulatory responses in wild house mice (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Zhang, Hongwei (WE 6)

Bednář, Lubomír

Heitlinger, Emanuel

Hartmann, Susanne (WE 6)

Rausch, Sebastian (WE 6)

Quelle

International Journal for Parasitology

Bandzählung: 52

Heftzählung: 8

Seiten: 519 – 524

ISSN: 0020-7519

Sprache

Englisch

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/abs/pii/S0020751922000807

DOI: 10.1016/j.ijpara.2022.03.006

Pubmed: 35533731

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Infections with high doses of intestinal nematodes result in protective immunity based on robust type 2 responses in most mouse lines under laboratory conditions. Here, we report on cellular responses of wild house mice from northern Germany. We detected robust Th1 responses in wild house mice naturally infected with the whipworm Trichuris muris. In contrast, mice infected with pinworms (Syphacia, Aspiculuris) reported type-2 activity by elevated IgG1 levels and eosinophil counts, but also harbored high frequencies of Foxp3+ regulatory T cells, suggesting that natural whip- and pinworm infections induce distinct immunoregulatory as well as effector profiles.