Publikationsdatenbank

Oxazolidinones:
mechanisms of resistance and mobile genetic elements involved (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Brenciani, Andrea

Morroni, Gianluca

Schwarz, Stefan (WE 7)

Giovanetti, Eleonora

Quelle

The journal of antimicrobial chemotherapy : JAC

Bandzählung: 77

Heftzählung: 10

Seiten: 2596 – 2621

ISSN: 0305-7453

Sprache

Englisch

Verweise

URL (Volltext): https://academic.oup.com/jac/article/77/10/2596/6672952

DOI: 10.1093/jac/dkac263

Pubmed: 35989417

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind to the peptidyl transferase centre of the bacterial ribosome inhibiting protein synthesis. Even if the majority of Gram-positive bacteria remain susceptible to oxazolidinones, resistant isolates have been reported worldwide. Apart from mutations, affecting mostly the 23S rDNA genes and selected ribosomal proteins, acquisition of resistance genes (cfr and cfr-like, optrA and poxtA), often associated with mobile genetic elements [such as non-conjugative and conjugative plasmids, transposons, integrative and conjugative elements (ICEs), prophages and translocatable units], plays a critical role in oxazolidinone resistance. In this review, we briefly summarize the current knowledge on oxazolidinone resistance mechanisms and provide an overview on the diversity of the mobile genetic elements carrying oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria.