Publication Database

Mobilization of tet(X4) by IS 1 family elements in porcine Escherichia coli isolates (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Yu, Runhao

Chen, Zheng

Schwarz, Stefan (WE 7)

Yao, Hong

Du, Xiang-Dang

Quelle

Antimicrobial agents and chemotherapy

Bandzählung: 66

Heftzählung: 1

Seiten: Artikel e01597-21

ISSN: 1098-6596

Sprache

Englisch

Verweise

URL (Volltext): https://journals.asm.org/doi/10.1128/AAC.01597-21

DOI: 10.1128/AAC.01597-21

Pubmed: 34723627

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The dissemination mechanism of the high-level tigecycline resistance gene tet(X4) in porcine Escherichia coli was investigated. tet(X4) and other antimicrobial resistance genes were located on the plasmids p1919D3-1 and p1919D62-1 and flanked by two or three copies of IS1 family elements, which can form one to three translocatable units (TUs). Using a reduced transposition model, IS1A was experimentally demonstrated to mediate the transposition of tet(X4) from a suicide plasmid into the E. coli chromosome.