Publication Database

A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58 (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Reid, Cameron J.

Cummins, Max L.

Börjesson, Stefan

Brouwer, Michael S. M.

Hasman, Henrik

Hammerum, Anette M.

Roer, Louise

Hess, Stefanie

Berendonk, Thomas

Nešporová, Kristina

Haenni, Marisa

Madec, Jean-Yves

Bethe, Astrid (WE 7)

Michael, Geovana B. (WE 7)

Schink, Anne-Kathrin (WE 7)

Schwarz, Stefan (WE 7)

Dolejska, Monika

Djordjevic, Steven P.

Quelle

Nature Communications

Bandzählung: 13

Heftzählung: 1

Seiten: Article number: 683

ISSN: 2041-1723

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41467-022-28342-4

DOI: 10.1038/s41467-022-28342-4

Pubmed: 35115531

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.