Publikationsdatenbank

Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV):
a threat for xenotransplantation? (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Mueller, Nicolas J.

Denner, Joachim (WE 5)

Quelle

Xenotransplantation : the official journal of the International Xenotransplantation Association, a section of The Transplantation Society

Bandzählung: 29

Heftzählung: 5

Seiten: Artikel e12775

ISSN: 1399-3089

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1111/xen.12775

DOI: 10.1111/xen.12775

Pubmed: 36082418

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The potential for a donor-derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation. This review gives a short description of the viral properties and summarizes the current evidence of the effects of PCMV/PRV transmission in preclinical xenotransplantation. Despite evidence that PCMV/PRV does not infect human and non-human primate cells, activation in the transplanted organ and detrimental systemic complications have been described. As PCMV/PRV is a herpesvirus able to establish latency, the importance of adequate screening of donor pigs is emphasized, as no efficient treatment is available. Furthermore, easy and successful ways of elimination of PCMV/PRV from pig herds are indicated.