Publication Database

Emerging viruses:
cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Tian, Jin

Sun, Jiumeng

Li, Dongyan

Wang, Ningning

Wang, Lifang

Zhang, Chang

Meng, Xiaorong (WE 5)

Ji, Xiang

Suchard, Marc A.

Zhang, Xu

Lai, Alexander

Su, Shuo

Veit, Michael (WE 5)

Quelle

Cell reports

Bandzählung: 39

Heftzählung: 11

Seiten: Artikel 110969

ISSN: 2211-1247

Sprache

Englisch

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/pii/S2211124722007550

DOI: 10.1016/j.celrep.2022.110969

Pubmed: 35679864

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Emerging infectious diseases, especially if caused by bat-borne viruses, significantly affect public health and the global economy. There is an urgent need to understand the mechanism of interspecies transmission, particularly to humans. Viral genetics; host factors, including polymorphisms in the receptors; and ecological, environmental, and population dynamics are major parameters to consider. Here, we describe the taxonomy, geographic distribution, and unique traits of bats associated with their importance as virus reservoirs. Then, we summarize the origin, intermediate hosts, and the current understanding of interspecies transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, Nipah, Hendra, Ebola, Marburg virus, and rotaviruses. Finally, the molecular interactions of viral surface proteins with host cell receptors are examined, and a comparison of these interactions in humans, intermediate hosts, and bats is conducted. This uncovers adaptive mutations in virus spike protein that facilitate cross-species transmission and risk factors associated with the emergence of novel viruses from bats.