Publikationsdatenbank

Determination of reference intervals for nonesterified fatty acids in the blood serum of healthy dogs (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Doll, Sophie‐Charlotte K. (WE 19)

Haimerl, Peggy (WE 19)

Bartel, Alexander (WE 16)

Arlt, Sebastian P. (WE 19)

Quelle

Vet record open

Bandzählung: 9

Heftzählung: 1

Seiten: Artikel e40

ISSN: 2052-6113

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1002/vro2.40

DOI: 10.1002/vro2.40

Pubmed: 35903267

Kontakt

Institut für Veterinär-Epidemiologie und Biometrie

Königsweg 67
14163 Berlin
+49 30 838 56034
epi@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Nonesterified fatty acids (NEFAs) are an important energy substrate inmammals. Measurement of the NEFA concentration in blood serum is common prac-tice and enables reliable detection of a negative energy balance in several species. Thisparameter can be used to detect subclinical metabolic diseases or to optimise feedingto prevent severe negative energy balance. Since no reference values for dogs have beenpublished, the aim of this study was to establish such values.

Methods:
Blood serum from 85 healthy dogs was examined with a multiparameter clin-ical chemistry analyser. Given that NEFA values are not usually normally distributed,reference intervals (RIs) were calculated nonparametrically using bootstrapping (5000replicates) for the 90% confidence intervals.

Results:
The examined cohort had a median age of 62.16 months (2–180 months) and amedian weight of 19.2 kg (3.0–55.0 kg) and comprised 27 (31.8%) males and 58 (68.2%)females, with 32 (37.6%) neutered or spayed. The fasting time was 5.9 h (range 0–23 h).The tested confounders age, sex, neuter status, bodyweight and body condition scoredid not significantly affect the NEFA concentrations.

Conclusions:
The NEFA RI for dogs in this study was 0.2–1.47 mmol/L. The results maybe used to adjust food composition and amount in healthy dogs or to detect metabolicdisorders. Further research on NEFA metabolism in dogs maintained in standardisedconditions and in specific nutritional situations or with particular diseases is warranted.