Publication Database

Origin and global expansion of Mycobacterium tuberculosis complex Lineage 3 (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Shuaib, Yassir A. (WE 7)

Utpatel, Christian

Kohl, Thomas A.

Barilar, Ivan

Diricks, Margo

Ashraf, Nadia

Wieler, Lothar H. (WE 7)

Kerubo, Glennah

Mesfin, Eyob A.

Diallo, Awa Ba

Al-Hajoj, Sahal

Ndung’u, Perpetua

Fitzgibbon, Margaret M.

Vaziri, Farzam

Sintchenko, Vitali

Martinez, Elena

Viegas, Sofia O.

Zhou, Yang

Azmy, Aya

Al-Amry, Khaled

Godreuil, Sylvain

Varma-Basil, Mandira

Narang, Anshika

Ali, Solomon

Beckert, Patrick

Dreyer, Viola

Kabwe, Mwila

Bates, Matthew

Hoelscher, Michael

Rachow, Andrea

Gori, Andrea

Tekwu, Emmanuel M.

Sidze, Larissa K.

Jean-Paul, Assam A.

Beng, Veronique P.

Ntoumi, Francine

Frank, Matthias

Diallo, Aissatou Gaye

Mboup, Souleymane

Tessema, Belay

Beyene, Dereje

Khan, Sadiq N.

Diel, Roland

Supply, Philip

Maurer, Florian P.

Hoffmann, Harald

Niemann, Stefan

Merker, Matthias

Quelle

Genes

Bandzählung: 13

Heftzählung: 6

Seiten: Artikel 990

ISSN: 2073-4425

Sprache

Englisch

Verweise

URL (Volltext): https://www.mdpi.com/2073-4425/13/6/990

DOI: 10.3390/genes13060990

Pubmed: 35741753

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-East and East Africa. This study provides a systematic understanding of the global diversity of L3 strains and reports phylogenetic variations that could inform clinical trials which evaluate the effectivity of new drugs/regimens or vaccine candidates.