Publikationsdatenbank

Effects of oral glutamine supplementation on jejunal morphology, development, and amino acid profiles in male low birth weight suckling piglets (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Schregel, Johannes

Schulze Holthausen, Johannes (WE 4)

Sciascia, Quentin L.

Li, Zeyang

Görs, Solvig

Eggert, Anja

Tuchscherer, Armin

Zentek, Jürgen (WE 4)

Metges, Cornelia C.

Quelle

PLOS ONE

Bandzählung: 17

Heftzählung: 4

Seiten: Artikel e0267357

ISSN: 1932-6203

Sprache

Englisch

Verweise

URL (Volltext): https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267357

DOI: 10.1371/journal.pone.0267357

Pubmed: 35476806

Kontakt

Institut für Tierernährung

Königin-Luise-Str. 49
14195 Berlin
+49 30 838 52256
tierernaehrung@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
It has been shown that small intestine development in low birth weight (LBW) piglets is impaired. Glutamine (Gln) has been reported to improve piglet health and intestinal function in weaned piglets, but data is scarce in suckling piglets. This study was conducted to investigate the effects of oral Gln supplementation compared to Alanine (Ala) on jejunal development and function in 5 and 12 d old male LBW and normal birth weight (NBW) suckling piglets.

Results:
Gln had no effect on the jejunal morphology, development, tissue and digesta amino acid profiles and mRNA abundance of genes involved in amino acid transport, metabolism, glutathione synthesis in LBW piglets when compared to Ala supplementation and birth weight controls at 5 and 12 d. Only the concentration of Gln in jejunal tissue was higher in NBW piglets supplemented with Gln compared to Ala at 5 d (P < 0.05). A comparison of the birth weight groups showed no differences between LBW and NBW piglets at 5 and 12 d in any parameter. Jejunal crypt depth, villus height / width, tunica muscularis thickness, number of goblet and IgA positive cells, the ratio of jejunal RNA to DNA and the concentration of DNA, protein and RNA changed (P < 0.05) from 5 compared to 12 d. The concentrations of several free, and protein bound amino acids as well as amino metabolites differed between age groups in jejunal tissue but the digesta concentrations were affected to a lesser extent.

Conclusions:
Oral Gln supplementation to suckling male piglets over the first 12 d of life was not associated with changes in jejunal parameters measured in this study. The absence of effects may indicate that Gln is absorbed as well as metabolized in the upper intestinal tract and thus could benefit intestinal development at a more proximal location.