Publikationsdatenbank

Efficacy of oral fluralaner (Bravecto) against Tunga penetrans in dogs:
a negative control, randomized field study in an endemic community in Brazil (2022)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

dos Santos, Katharine Costa

Chiummo, Rafael Marin

Heckeroth, Anja Regina

Zschiesche, Eva

Brandão Guedes, Paula Elisa

Harvey, Tatiani Vitor

de Jesus, Anderson Vieira

da Paixão Sevá, Anaiá

de Oliveira, Joana Thaisa Santos

dos Santos Freire, Zelina

Krücken, Jürgen (WE 13)

de Almeida Borges, Fernando

von Samson-Himmelstjerna, Georg (WE 13)

Alberto Carlos, Renata Santiago

Quelle

PLoS Neglected Tropical Diseases

Bandzählung: 16

Heftzählung: 3

Seiten: Artikel e0010251

ISSN: 1935-2727

Sprache

Englisch

Verweise

URL (Volltext): https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010251

DOI: 10.1371/journal.pntd.0010251

Pubmed: 35286319

Kontakt

Institut für Parasitologie und Tropenveterinärmedizin

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 62310
parasitologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The sand flea Tunga penetrans is one of the zoonotic agents of tungiasis, a parasitic skin disease of humans and animals. The dog is one of its main reservoirs. This negatively controlled, randomized, double-masked clinical trial evaluated the therapeutic and residual efficacy of fluralaner for treatment of dogs naturally infested with T. penetrans. Sixty-two dogs from an endemically affected community in Brazil were randomly assigned to either receive oral fluralaner (Bravecto chewable tablets) at a dose of 25 to 56 mg fluralaner/kg body weight, or no treatment (31 dogs per group). Dogs were clinically examined using a severity score for acute canine tungiasis (SCADT), parasitological examinations as defined by the Fortaleza classification, and pictures of lesions on days 0 (inclusion and treatment), 7 ± 2, 14 ± 2, 21 ± 2, 28 ± 2, 60 ± 7, 90 ± 7, 120 ± 7 and 150 ± 7. The percentage of parasite-free dogs after treatment was >90% between days 14 and 90 post-treatment with 100% efficacy on study days 21, 28 and 60. Sand flea counts on fluralaner treated dogs were significantly lower (p<0.025) than control dogs on all counts from day 7 to 120. The number of live sand fleas on treated dogs was reduced by > 90% on day 7, > 95% on days 14 and 90, and 100% from day 21 to 60, and with a significant difference between groups from day 7 to 120. From day 7 to day 120, mean SCADT scores were significantly reduced in treated dogs with a mean of 0.10 compared to 1.54 on day 120 in untreated dogs. Therefore, a single oral fluralaner administration is effective for treating and achieving long lasting (> 12 weeks) prevention for tungiasis in dogs.