Publikationsdatenbank

Breeding and maintenance of immunodeficient mouse lines under SPF conditions:
a call for individualized severity analyses and approval procedures (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kammertoens, Thomas

Jeuthe, Sarah

Baranzke, Heike

Klippert, Antonina

Thöne-Reineke, Christa (WE 11)

Quelle

Animals

Bandzählung: 11

Heftzählung: 6

Seiten: Artikel 1789

ISSN: 2076-2615

Sprache

Englisch

Verweise

URL (Volltext): https://www.mdpi.com/2076-2615/11/6/1789

DOI: 10.3390/ani11061789

Pubmed: 34203900

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods are available. However, the breeding of immunodeficient mice is considered an experiment requiring a permit, even if no pain, suffering or harm is observed under scientifically required defined hygienic housing conditions, as determined by established methods of severity assessment. This seems contradictory and leads to uncertainty among scientists. With this commentary, we would like to shed light on this topic from different perspectives and propose a solution in terms of individualized severity assessment and approval procedures.