Publikationsdatenbank

SIGLEC1 (CD169):
a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Ostendorf, Lennard

Dittert, Philipp

Biesen, Robert

Duchow, Ankelien

Stiglbauer, Victoria

Ruprecht, Klemens

Bellmann-Strobl, Judith

Seelow, Dominik

Stenzel, Werner

Niesner, Raluca A. (WE 2)

Hauser, Anja E.

Paul, Friedemann

Radbruch, Helena

Quelle

Scientific reports

Bandzählung: 11

Heftzählung: 1

Seiten: Article number: 10299

ISSN: 2045-2322

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41598-021-89786-0

DOI: 10.1038/s41598-021-89786-0

Pubmed: 33986412

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

We aimed to evaluate SIGLEC1 (CD169) as a biomarker in multiple sclerosis (MS) and Neuromyelitis optica spectrum disorder (NMOSD) and to evaluate the presence of SIGLEC1+ myeloid cells in demyelinating diseases. We performed flow cytometry-based measurements of SIGLEC1 expression on monocytes in 86 MS patients, 41 NMOSD patients and 31 healthy controls. Additionally, we histologically evaluated the presence of SIGLEC1+ myeloid cells in acute and chronic MS brain lesions as well as other neurological diseases. We found elevated SIGLEC1 expression in 16/86 (18.6%) MS patients and 4/41 (9.8%) NMOSD patients. Almost all MS patients with high SIGLEC1 levels received exogenous interferon beta as an immunomodulatory treatment and only a small fraction of MS patients without interferon treatment had increased SIGLEC1 expression. In our cohort, SIGLEC1 expression on monocytes was-apart from those patients receiving interferon treatment-not significantly increased in patients with MS and NMOSD, nor were levels associated with more severe disease. SIGLEC1+ myeloid cells were abundantly present in active MS lesions as well as in a range of acute infectious and malignant diseases of the central nervous system, but not chronic MS lesions. The presence of SIGLEC1+ myeloid cells in brain lesions could be used to investigate the activity in an inflammatory CNS lesion.