Publikationsdatenbank

One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Ahmadi, Vahid

Nie, Chuanxiong

Mohammadifar, Ehsan

Achazi, Katharina

Wedepohl, Stefanie

Kerkhoff, Yannic

Block, Stephan

Osterrieder, Nikolaus (WE 5)

Haag, Rainer

Quelle

Chemical communications : ChemComm

Bandzählung: 57

Heftzählung: 90

Seiten: 11948 – 11951

ISSN: 1364-548x

Sprache

Englisch

Verweise

URL (Volltext): https://pubs.rsc.org/en/content/articlelanding/2021/CC/D1CC04703E

DOI: 10.1039/D1CC04703E

Pubmed: 34671786

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.