Publikationsdatenbank

In vitro efficacy of Artemisia extracts against SARS-CoV-2 (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Nie, Chuanxiong

Trimpert, Jakob (WE 5)

Moon, Sooyeon

Haag, Rainer

Gilmore, Kerry

Kaufer, Benedikt B. (WE 5)

Seeberger, Peter H.

Quelle

Virology journal

Bandzählung: 18

Heftzählung: 1

Seiten: Article number: 182

ISSN: 1743-422x

Sprache

Englisch

Verweise

URL (Volltext): https://virologyj.biomedcentral.com/articles/10.1186/s12985-021-01651-8

DOI: 10.1186/s12985-021-01651-8

Pubmed: 34496903

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19.

Methods:
The plant extracts and Covid-Organics drink produced in Madagascar were tested for plaque reduction using both feline coronavirus and SARS-CoV-2 in vitro. Their cytotoxicities were also investigated.

Results:
Several extracts as well as Covid-Organics inhibited SARS-CoV-2 and FCoV infection at concentrations that did not affect cell viability.

Conclusions:
Some plant extracts show inhibitory activity against FCoV and SARS-CoV-2. However, it remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral infection following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment of patients.