Publikationsdatenbank

Pathways to clinical cardiac xenotransplantation (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Reichart, Bruno

Längin, Matthias

Denner, Joachim (WE 5)

Schwinzer, Reinhard

Cowan, Peter J.

Wolf, Eckhard

Quelle

Transplantation : the official journal of the Transplantation Society

Bandzählung: 105

Heftzählung: 9

Seiten: 1930 – 1943

ISSN: 1534-6080

Sprache

Englisch

Verweise

URL (Volltext): https://journals.lww.com/transplantjournal/Fulltext/2021/09000/Pathways_to_Clinical_Cardiac_Xenotransplantation.14.aspx

DOI: 10.1097/TP.0000000000003588

Pubmed: 33350675

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Heart transplantation is the only long-lasting lifesaving option for patients with terminal cardiac failure. The number of available human organs is however far below the actual need, resulting in substantial mortality of patients while waiting for a human heart. Mechanical assist devices are used to support cardiac function but are associated with a high risk of severe complications and poor quality of life for the patients. Consistent success in orthotopic transplantation of genetically modified pig hearts into baboons indicates that cardiac xenotransplantation may become a clinically applicable option for heart failure patients who cannot get a human heart transplant. In this overview, we project potential paths to clinical cardiac xenotransplantation, including the choice of genetically modified source pigs; associated requirements of microbiological, including virological, safety; optimized matching of source pig and recipient; and specific treatments of the donor heart after explantation and of the recipients. Moreover, selection of patients and the regulatory framework will be discussed.