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    Endogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines (2021)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autor
    Denner, Joachim (WE 5)
    Quelle
    Translational oncology
    Bandzählung: 14
    Heftzählung: 1
    Seiten: Artikel 100941
    ISSN: 1936-5233
    Sprache
    Englisch
    Verweise
    URL (Volltext): https://www.sciencedirect.com/science/article/pii/S1936523320304332
    DOI: 10.1016/j.tranon.2020.100941
    Pubmed: 33221683
    Kontakt
    Institut für Virologie

    Robert-von-Ostertag-Str. 7-13
    14163 Berlin
    +49 30 838 51833
    virologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Many tumour cells express on their surface proteins of endogenous retroviruses (ERVs) and there are suggestions to use these retroviral antigens as target for anti-tumour vaccines. However, until now there is no convincing data showing that this strategy works, in contrast, there are considerations suggesting that this strategy may be harmful if applied.