Publikationsdatenbank

Functional changes of immune cells:
signal of immune tolerance of the ectopic lesions in endometriosis? (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Voltolini Velho, Renata

Halben, Nicolette

Chekerov, Radoslav

Keye, Jacqueline

Plendl, Johanna (WE 1)

Sehouli, Jalid

Mechsner, Sylvia

Quelle

Reproductive biomedicine online : RBM online

Bandzählung: 43

Heftzählung: 2

Seiten: 319 – 328

ISSN: 1472-6491

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/abs/pii/S1472648321001887

DOI: 10.1016/j.rbmo.2021.04.012

Pubmed: 34103260

Kontakt

Institut für Veterinär-Anatomie

Koserstr. 20
14195 Berlin
+49 30 838 75784
anatomie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Research Question:
What is the potential role of immune cells and their inflammatory cytokines in the pathogenesis, development and establishment of endometriosis (EM)?

Design:
Peritoneal fluid (PF) from 59 women (43 patients with EM and 16 controls) who had undergone laparoscopic surgery were analyzed. Changes in innate and adaptive immune cells population, as well as, cytokines, chemokines, and growth factors expression were measured by flow cytometry, Luminex Technology and ELISA.

Results:
The frequencies of the innate and adaptive immune cells were not different between nonendometriosis and EM patients. IL-1β, IL-1RN, IL-2, IL-4, IL-8, IL-10, IL-12, IL-17α, FGF2, G-CSF, MCP-1, MIP-1α, TNF-α were significantly increased in the PF of the women with EM when compared with the controls. A correlation between IL-2, MCP-1, MIP-1α, TNF-α and EM severity were noted. Furthermore, the concentration of neopterin, a possible biomarker for this disease, in EM patients was increased compared to controls.

Conclusions:
Although their numbers remained unchanged, functional activity of immune cells seemed to be reduced. We suggest that a shift between TH cytokine profile occurs and our data indicate that is TH1 over TH2 response by the cytokines increased in the severe affect group of patients with EM (TNF-α and IL-2).