Publikationsdatenbank

Prevalence and characterization of hypoadrenocorticism in dogs with signs of chronic gastrointestinal disease:
a multicenter study (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Hauck, Christina

Schmitz, Silke S.

Burgener, Iwan A.

Wehner, Astrid

Neiger, Reto

Kohn, Barbara (WE 20)

Rieker, Thomas

Reese, Sven

Unterer, Stefan

Quelle

Journal of veterinary internal medicine

Bandzählung: 34

Heftzählung: 4

Seiten: 1399 – 1405

ISSN: 0891-6640

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.15752

DOI: 10.1111/jvim.15752

Pubmed: 32573832

Kontakt

Klein- und Heimtierklinik

Oertzenweg 19 b
14163 Berlin
+49 30 838 62422
kleintierklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Dogs with hypoadrenocorticism (HA) frequently show signs of gastrointestinal disease (SGD). The prevalence of dogs presented for chronic SGD with HA is unknown.

Objectives:
The aims of this study were to determine the prevalence of HA in dogs with chronic SGD and to identify clinical and laboratory variables for HA in this population.

Animals:
One hundred fifty‐one dogs with chronic SGD.

Methods:
In this multicentered prevalence study a standardized workup was performed in prospectively enrolled dogs with SGD > 3 weeks duration. Basal serum cortisol concentration was measured in every dog with ACTH stimulation test (ACTHST) if basal serum cortisol concentration was <3 μg/dL.

Results:
Basal serum cortisol concentration was <3 μg/dL in 80/151 (53%) dogs, <2 μg/dL in 42/151 (28%) dogs, and < 1 μg/dL in 9/151 (6%) dogs. In 6/151 dogs HA was diagnosed based on ACTHST (stimulated serum cortisol concentration < 2 μg/dL), a prevalence of 4%. There was no difference in history, physical examination, and laboratory variables between dogs with HA and those with other causes of chronic SGD. In 4/6 dogs with HA, there was melena or hematochezia indicating gastrointestinal blood loss. Hyperkalemia, hyponatremia, or both was not observed in any dog.

Conclusion and Clinical Importance:
The prevalence of HA among dogs with chronic SGD is higher than in the general population. Based on these results, testing adrenal function should be performed as a standard screening test in dogs with chronic SGD to differentiate between HA and chronic enteropathies.