Publication Database

Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Hecht-Höger, Alexander M.

Braun, Beate C.

Krause, Eberhard

Meschede, Angelika

Krahe, Rüdiger

Voigt, Christian C.

Greenwood, Alex D. (WE 5)

Czirják, Gábor Á.

Quelle

Molecular ecology

Bandzählung: 29

Heftzählung: 9

Seiten: 1745 – 1755

ISSN: 0962-1083

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/epdf/10.1111/mec.15437

DOI: 10.1111/mec.15437

Pubmed: 32279365

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Emerging fungal diseases have become challenges for wildlife health and conservation. North American hibernating bat species are threatened by the psychrophilic fungus Pseudogymnoascus destructans (Pd) causing the disease called white-nose syndrome (WNS) with unprecedented mortality rates. The fungus is widespread in North America and Europe, however, disease is not manifested in European bats. Differences in epidemiology and pathology indicate an evolution of resistance or tolerance mechanisms towards Pd in European bats. We compared the proteomic profile of blood plasma in healthy and Pd-colonized European Myotis myotis and North American Myotis lucifugus in order to identify pathophysiological changes associated with Pd colonization, which might also explain the differences in bat survival. Expression analyses of plasma proteins revealed differences in healthy and Pd-colonized M. lucifugus, but not in M. myotis. We identified differentially expressed proteins for acute phase response, constitutive and adaptive immunity, oxidative stress defence, metabolism and structural proteins of exosomes and desmosomes, suggesting a systemic response against Pd in North American M. lucifugus but not European M. myotis. The differences in plasma proteomic profiles between European and North American bat species colonized by Pd suggest European bats have evolved tolerance mechanisms towards Pd infection.