Publikationsdatenbank

Equid herpesvirus-1 exploits the extracellular matrix of mononuclear cells to ensure transport to target cells (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kamel, Mohamed

Pavulraj, Selvaraj

Fauler, Beatrix

Mielke, Thorsten

Azab, Walid (WE 5)

Quelle

iScience

Bandzählung: 23

Heftzählung: 10

Seiten: Artikel 101615

ISSN: 2589-0042

Sprache

Englisch

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/pii/S2589004220308075

DOI: 10.1016/j.isci.2020.101615

Pubmed: 33015592

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mononuclear cells are the first line of defense against microbial infection. Yet, several viruses have evolved different mechanisms to overcome host defenses to ensure their spread. Here, we show unique mechanisms of how equid herpesvirus-1 manipulates peripheral blood mononuclear cells (PBMC) to travel further in the body. (1) “PBMC-hitching”: at the initial contact, herpesviruses lurk in the extracellular matrix (ECM) of PBMC without entering the cells. The virus exploits the components of the ECM to bind, transport, and then egress to infect other cells. (2) “Intracellular delivery”: transendothelial migration is a physiological mechanism where mononuclear cells can transmigrate through the endothelial cells. The virus was intangible and probably did not interfere with such a mechanism where the infected PBMC can probably deliver the virus inside the endothelium. (3) “Classical-fusion”: this process is well mastered by herpesviruses due to a set of envelope glycoproteins that facilitate cell-cell fusion and virus spread.