Publikationsdatenbank

Is the magnesium metabolism altered in horses with insulin dysregulation? (2020)

Art

Vortrag

Autoren

Winter, Judith C. (WE 17)

Müller, Eva (WE 17)

Sponder, Gerhard (WE 2)

Merle, Roswitha (WE 16)

Aschenbach, Jörg R. (WE 2)

Gehlen, Heidrun (WE 17)

Kongress

4 th Global Equine Endocrine Symposium

Gut Ising, Bavaria, Germany, 06. – 10.01.2020

Quelle

Proceedings : 4 th Global Equine Endocrine Symposium : Gut Ising, Bavaria, Germany : January 6 th - 10 th 2020 — Symposium commitee Andy Durham, Nicholas Frank, Catherine McGowan, Harold Schott, Allison Stewart, Melody de Laat ; hosted by Boehringer Ingelheim (Hrsg.)

— S. 59

Sprache

Englisch

Verweise

URL (Volltext): https://sites.tufts.edu/equineendogroup/files/2020/01/GEES_2020_Proceedings.pdf

Kontakt

Institut für Veterinär-Epidemiologie und Biometrie

Königsweg 67
14163 Berlin
+49 30 838 56034
epi@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The Equine Metabolic Syndrome (EMS) is one of the most common endocrinopathies in horses worldwide with parallels to human Diabetes mellitus type 2. In both diseases, patients show an insulin dysregulation as a key feature. Magnesium metabolism, especially the intracellular magnesium concentration [Mg2+]i, plays an important role in human diabetes mellitus. These patients often exhibit a magnesium deficit in the serum or at the cellular level and multiple studies have demonstrated the beneficial effect of magnesium supplementation on insulin sensitivity. The aim of this study was to evaluate [Mg2+]i in horses with insulin resistance and to examine a possible association with other markers of insulin dysregulation. The hypothesis was tested, that [Mg2+]i is inversely correlated with parameters of insulin resistance. The study included 38 horses with a positive combined glucose insulin tolerance test (CGIT) and phenotypic signs of EMS. Baseline glucose (G0), glucose curve, baseline insulin (I0), insulin after 45 minutes (I45), total serum magnesium concentration and [Mg2+]i were measured. The reciprocal inverse square of insulin (RISQI), the modified insulin-to-glucose ratio (MIRG) and the insulin difference (I45-0) were calculated. A t-test for independent samples was used to compare [Mg2+]i in healthy and EMS horses. Linear regression analyses with uni- and multivariable models were calculated to evaluate the influence of [Mg2+]i on all other blood and clinical parameters in EMS horses. Compared to healthy controls, [Mg2+]i was significantly lower in horses with EMS (P = 0.015). Univariable linear regression models showed significant associations between I0 (P = 0.004, b = 0.006), I45 (P = 0.006, b = 0.001), I45-0 (P = 0.008, b = 0.001), RISQI (P = 0.009, b = -0.158), MIRG (P < 0.001, b = 0.015) and [Mg2+]i. The multivariable model revealed that only MIRG was significantly associated with [Mg2+]i whereas the other factors had no additional influence. Horses with insulin dysregulation exhibited a significantly lower [Mg2+]i than healthy horses, what can partially be reversed by increased secretion of insulin. These findings substantiate the important interconnection of the insulin and magnesium metabolism and its relevance in Equine metabolic Syndrome.