Publikationsdatenbank

Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Jeuthe, Sarah

Kemna, Josephine

Kemna, Christoph Philipp

Zocholl, Dario

Klopfleisch, Robert (WE 12)

Palme, Rupert

Kirschbaum, Clemens

Thoene-Reineke, Christa (WE 11)

Kammertoens, Thomas

Quelle

PLOS ONE

Bandzählung: 15

Heftzählung: 9

Seiten: Artikel e0239231

ISSN: 1932-6203

Sprache

Englisch

Verweise

URL (Volltext): https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239231

DOI: 10.1371/journal.pone.0239231

Pubmed: 32997686

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice.