Publikationsdatenbank

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Jumaa, Huda

Caganova, Marieta

McAllister, Ellen J.

Hoenig, Laura

He, Xiaocui

Saltukoglu, Deniz

Brenker, Kathrin

Köhler, Markus

Leben, Ruth

Hauser, Anja E.

Niesner, Raluca (WE 2)

Rajewsky, Klaus

Reth, Michael

Jellusova, Julia

Quelle

Life science alliance

Bandzählung: 3

Heftzählung: 6

Seiten: Artikel e202000700

ISSN: 2575-1077

Sprache

Englisch

Verweise

URL (Volltext): https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000700

DOI: 10.26508/lsa.202000700

Pubmed: 32341085

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor survive in the periphery. Here, we show that the loss of BCR expression on Burkitt lymphoma cells leads to decreased mitochondrial function and impaired metabolic flexibility. Strikingly, this phenotype does not result from the absence of a classical Syk-dependent BCR signal but rather from compromised ER expansion. We show that the reexpression of immunoglobulins (Ig) in the absence of the BCR signaling subunits Igα and Igβ rescues the observed metabolic defects. We demonstrate that immunoglobulin expression is needed to maintain ER homeostasis not only in lymphoma cells but also in resting B cells. Our study provides evidence that the expression of BCR components, which is sensed in the ER and shapes mitochondrial function, represents a novel mechanism of metabolic control in B cells.