Publikationsdatenbank

Latest insights into Marek's disease virus pathogenesis and tumorigenesis (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Bertzbach, Luca D. (WE 5)

Conradie, Andelé M. (WE 5)

You, Yu (WE 5)

Kaufer, Benedikt B. (WE 5)

Quelle

Cancers

Bandzählung: 12

Heftzählung: 3

Seiten: 647

ISSN: 2072-6694

Sprache

Englisch

Verweise

URL (Volltext): https://www.mdpi.com/2072-6694/12/3/647

DOI: 10.3390/cancers12030647

Pubmed: 32164311

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Marek's disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research.