Publikationsdatenbank

Myocardial infarction after high-dose catecholamine application:
a case report from an experimental imaging study (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Beyhoff, Niklas

Lohr, David

Thiele, Arne

Foryst-Ludwig, Anna

Klopfleisch, Robert (WE 12)

Schreiber, Laura M.

Kintscher, Ulrich

Quelle

Frontiers in Cardiovascular Medicine

Bandzählung: 7

Seiten: Article 580296

ISSN: 2297-055x

Sprache

Englisch

Verweise

URL (Volltext): https://www.frontiersin.org/articles/10.3389/fcvm.2020.580296/full

DOI: 10.3389/fcvm.2020.580296

Pubmed: 33330644

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Although heart failure following myocardial infarction (MI) represents a major health burden, underlying microstructural and functional changes remain incompletely understood. Here, we report on a case of unexpected MI after treatment with the catecholamine isoproterenol in an experimental imaging study in mice using different state-of-the-art imaging modalities. The decline in cardiac function was documented by ultrahigh-frequency echocardiography and speckle-tracking analyses. Myocardial microstructure was studied ex vivo at a spatial resolution of 100 × 100 × 100 μm3 using diffusion tensor magnetic resonance imaging (DT-MRI) and histopathologic analyses. Two weeks after ISO treatment, the animal showed an apical aneurysm accompanied by reduced radial strain in corresponding segments and impaired global systolic function. DT-MRI revealed a loss of contractile fiber tracts together with a disarray of remaining fibers as corresponding microstructural correlates. This preclinical case report provides valuable insights into pathophysiology and morphologic-functional relations of heart failure following MI using emerging imaging technologies.