Publikationsdatenbank

Surface distribution of pyrethroids following topical application to veterinary species:
implications for lateral transport (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Bäumer, Wolfgang (WE 14)

Baynes, Ronald

Quelle

Journal of veterinary pharmacology and therapeutics

Bandzählung: 44

Heftzählung: 1

Seiten: 1 – 10

ISSN: 1365-2885

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1111/jvp.12907

DOI: 10.1111/jvp.12907

Pubmed: 32910498

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Pyrethroids like permethrin have been used as topical formulations for their ectoparasiticidal effects since the 1970s. There are numerous efficacy studies in dogs and livestock animals that indicate a fast spread of pyrethroids after topical administration onto rather confined areas of the skin. Some studies correlate the efficacy against ticks, fleas or lice with concentrations of pyrethroids in hair and, less frequently, stratum corneum samples. It is often stated that lateral transport is responsible for the distribution of the pyrethroids over the body surface. With this review, we attempt to demonstrate evidence for lateral transport of pyrethroids after topical administration in dogs, cattle and sheep and to present data gaps that should be addressed in follow-up studies.