Publikationsdatenbank

Not part of the temporal lobe, but still of importance?
Substantia nigra and subthalamic nucleus in epilepsy (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autor

Bröer, Sonja (WE 14)

Quelle

Frontiers in systems neuroscience

Bandzählung: 14

Seiten: Article 581826

ISSN: 1662-5137

Sprache

Englisch

Verweise

URL (Volltext): https://www.frontiersin.org/articles/10.3389/fnsys.2020.581826/full

DOI: 10.3389/fnsys.2020.581826

Pubmed: 33381016

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The most researched brain region in epilepsy research is the temporal lobe, and more specifically, the hippocampus. However, numerous other brain regions play a pivotal role in seizure circuitry and secondary generalization of epileptic activity: The substantia nigra pars reticulata (SNr) and its direct input structure, the subthalamic nucleus (STN), are considered seizure gating nuclei. There is ample evidence that direct inhibition of the SNr is capable of suppressing various seizure types in experimental models. Similarly, inhibition via its monosynaptic glutamatergic input, the STN, can decrease seizure susceptibility as well. This review will focus on therapeutic interventions such as electrical stimulation and targeted drug delivery to SNr and STN in human patients and experimental animal models of epilepsy, highlighting the opportunities for overcoming pharmacoresistance in epilepsy by investigating these promising target structures.