Publikationsdatenbank

The circadian dynamics of the hippocampal transcriptome and proteome is altered in experimental temporal lobe epilepsy (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Debski, K. J.

Ceglia, N.

Ghestem, A.

Ivanov, A. I.

Brancati, G. E.

Bröer, S.

Bot, A. M.

Müller, J. A.

Schoch, S.

Becker, A.

Löscher, W.

Guye, M.

Sassone-Corsi, P.

Lukasiuk, K.

Baldi, P.

Bernard, C.

Quelle

Science advances

Bandzählung: 6

Heftzählung: 41

Seiten: eaat5979

ISSN: 2375-2548

Sprache

Englisch

Verweise

URL (Volltext): https://advances.sciencemag.org/content/6/41/eaat5979

DOI: 10.1126/sciadv.aat5979

Pubmed: 33036982

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Gene and protein expressions display circadian oscillations, which can be disrupted in diseases in most body organs. Whether these oscillations occur in the healthy hippocampus and whether they are altered in epilepsy are not known. We identified more than 1200 daily oscillating transcripts in the hippocampus of control mice and 1600 in experimental epilepsy, with only one-fourth oscillating in both conditions. Comparison of gene oscillations in control and epilepsy predicted time-dependent alterations in energy metabolism, which were verified experimentally. Although aerobic glycolysis remained constant from morning to afternoon in controls, it increased in epilepsy. In contrast, oxidative phosphorylation increased in control and decreased in epilepsy. Thus, the control hippocampus shows circadian molecular remapping, which is altered in epilepsy. We suggest that the hippocampus operates in a different functioning mode in epilepsy. These alterations need to be considered when studying epilepsy mechanisms, designing drug treatments, and timing their delivery.