Publikationsdatenbank

Periarticular histiocytic sarcoma in a domestic rabbit (2021)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Bertram, C. A. (WE 12)

Kuzminskiy, S. (WE 20)

Müller, K. (WE 20)

Mundhenk, L. (WE 12)

Quelle

The Journal of small animal practice : JSAP

Bandzählung: 62

Heftzählung: 5

Seiten: 404

ISSN: 0022-4510

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1111/jsap.13253

DOI: 10.1111/jsap.13253

Pubmed: 33210288

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Articular tumours have only rarely been described in rabbits (Oryctolagus cuniculus). An 8‐year‐old, male castrated, domestic rabbit was presented with progressive right hindlimb lameness and its owners requested humane euthanasia. Radiography and a full post‐mortem examination revealed a tumour in the location of the stifle joint with extension along tendon sheaths and extensive infiltration into the bone and bone marrow of the femur and tibia, the surrounding soft tissue and skeletal musculature (Fig 1A, B). Metastatic disease was not identified at post‐mortem examination. Following an established immunohistochemical protocol for rabbit tissues (supplemental information), tumour cells were strongly positive for the macrophage scavenger receptor CD204 and vimentin, however, showed no expression of cytokeratin and smooth‐muscle‐actin. Pathological findings were consistent with a localised, periarticular histiocytic sarcoma (Fig 1C).
In rabbits, disseminated or localised histiocytic sarcomas have been reported to be predominately located in the lungs and less commonly in abdominal organs and skin, however, not in periarticular locations. In contrast, localised histiocytic sarcomas are the most common tumour type of the synovium of diarthrodial joints in dogs and likely arise from type A synoviocytes, a cell type of the histiocytic lineage. Other tumours such as synovial cell sarcoma may arise in the location of the joint (some with controversial cell origin), however, immunohistochemical staining confirmed histiocytic lineage in the present case. Radiographic, gross and histological features of the present case were consistent with descriptions in dogs. Early treatment of articular histiocytic sarcoma, such as amputation, may be curative if no metastases are present. While rabbits commonly have disseminated histiocytic sarcoma, biological behaviour of these tumours in articular location is currently unknown.