Publikationsdatenbank

Farm animals and aquaculture:
significant reservoirs of mobile colistin resistance genes (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Shen, Yingbo

Zhang, Rong

Schwarz, Stefan (WE 7)

Wu, Congming

Shen, Jianzhong

Walsh, Timothy R.

Wang, Yang

Quelle

Environmental microbiology

Bandzählung: 22

Heftzählung: 7

Seiten: 2469 – 2484

ISSN: 1462-2912

Sprache

Englisch

Verweise

URL (Volltext): https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/1462-2920.14961

DOI: 10.1111/1462-2920.14961

Pubmed: 32114703

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Colistin resistance has attracted substantial attention after colistin was considered as a last-resort drug for the treatment of infections caused by carbapenem-resistant and/or multidrug-resistant (MDR) Gram-negative bacteria in clinical settings. However, with the discovery of highly mobile colistin resistance (mcr) genes, colistin resistance has become an increasingly urgent issue worldwide. Despite many reviews, which summarized the prevalence, mechanisms, and structures of these genes in bacteria of human and animal origin, studies on the prevalence of mobile colistin resistance genes in aquaculture and their transmission between animals and humans remain scarce. Herein, we review recent reports on the prevalence of colistin resistance genes in animals, especially wildlife and aquaculture, and their possibility of transmission to humans via the food chain. This review also gives some insights into the routine surveillance, changing policy and replacement of polymyxins by polymyxin derivatives, molecular inhibitors, and traditional Chinese medicine to tackle colistin resistance.