Publikationsdatenbank

Efficacy study of a topical treatment with a plant extract with antibiofilm activities using an in vivo model of canine superficial pyoderma (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Bäumer, Wolfgang (WE 14)

Jacobs, Megan

Tamamoto-Mochizuki, Chie

Quelle

Veterinary dermatology : an international journal

Bandzählung: 31

Heftzählung: 2

Seiten: 86 – e8

ISSN: 0959-4493

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/full/10.1111/vde.12808

DOI: 10.1111/vde.12808

Pubmed: 31737969

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Canine pyoderma is a common skin infection caused predominantly by staphylococcal bacteria.Because of increasing rates of antimicrobial resistance in bacterial isolates, there is an urgent need for alternativeor supplementary treatment options. W16P576, a Water Extract of Complex Mix of Edible Plants (WECMEP), hasshownin vitroactivity against a variety of bacteria, includingStaphylococcus pseudintermedius. A canine model ofpyoderma was developed which allowsin vivotesting of antimicrobial agents in a controlled environment.

Objective:
To evaluate the antibacterial efficacy of topical application of W16P576 in a model of canine pyoderma.

Animals:
Nine laboratory housed beagle dogs.

Methods and materials:
In an evaluator-blinded cross-over study with an eight week washout period, dogswere treated topically twice daily with W16P576 WECMEP or its vehicle, starting three days before bacterialchallenge. On the day of challenge, each dog was treated with two concentrations of a clinical S.pseudinter-mediusstrain on opposite sides of the body. Topical treatment was continued for 11 days and lesions of pyo-derma were evaluated and scored for 14 days.

Results:
All dogs developed lesions consistent with bacterial pyoderma. Lesion scores were generally higheron the side inoculated with a higher concentration of bacteria. Treatment with W16P576 significantly reducedlesion development and hastened resolution of lesions, compared to placebo.

Conclusion:
Topical application of W16P576 markedly reduced lesion development in this proof of principlestudy. Clinical trials are warranted to estimate benefits for dogs with naturally occurring pyoderma under fieldconditions.