Publikationsdatenbank

Characterization of recently emerging “high risk” Klebsiella pneumoniae ST307 isolated from the urinary tract of a dog (2019)

Art

Poster

Autoren

Bethe, A. (WE 7)

Eichhorn, I. (WE 7)

Weingart, C. (WE 20)

Roschanski, N.

Schink, A.-K. (WE 7)

Brombach, J. (WE 7)

Walther, B.

Kohn, B. (WE 20)

Lübke-Becker, A. (WE 7)

Kongress

Zoonoses 2019 - International Symposium on Zoonoses Research

Berlin, 16. – 18.10.2019

Quelle

Zoonoses 2019 - International Symposium on Zoonoses Research : Book of Abstracts — International Symposium on Zoonoses Research (Hrsg.)

Berlin, 2019 — S. 245

Sprache

Englisch

Verweise

URL (Volltext): https://evis.events/event/79/attachments/23/154/Book_of_Abstracts_Zoonoses2019.pdf

Kontakt

Klein- und Heimtierklinik

Oertzenweg 19 b
14163 Berlin
+49 30 838 62422
kleintierklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Klebsiellapneumoniae (Kp)-infections in humans and animalsare frequently associated with multi-drug resistant (MDR) phenotypes. In humanmedicine, the global spread of MDR Kpis linked to successful high-risk genetic lineages such as ST258 and the newly emerging ST307. Here, we report on multiple isolations of ST307 from a dog suffering from chronic urinary tract infection (UTI).All confirmed Kpisolates were whole-genome sequenced (WGS) using Illumina MiSeq. Genotypic characterization includedthe determination of sequence type (ST), transferable resistance genes and plasmids (https://cge.dtu.dk).Ten Kpisolates were identified, with five being in mixed culture withother bacterial species. All Kp belonged to ST307, six harbored an IncF-plasmid and were ESBL-positive (blaCTX-M-15). First phylogenetic analysis revealed a close relationship between the strains.Although genetic features that may provide an advantage in adaption to the human host have been reported for this lineage, blaCTX-M-15-MDR ST307 can cause UTI in companion animals.This is in accordance with a current study reporting ST307-blaCTX-M-15in canine and feline urine samples. As they can serve as source of infection for high-risk Kpclones, companion animals may pose a risk to their owners. Consequently, further investigation is needed to elucidate whether bacterial persistence may explain the detection of eight closely related isolates from a canine patient under antibiotic therapy in a one-year period.