Publikationsdatenbank

C. difficile may cause infections in reptiles (2019)

Art

Poster

Autoren

Rabold, D. (WE 7)

Mundhenk, L. (WE 12)

Seyboldt, C.

Lübke-Becker, A. (WE 7)

Kongress

Zoonoses 2019 - International Symposium on Zoonoses Research

Berlin, 16. – 18.10.2019

Quelle

Zoonoses 2019 - International Symposium on Zoonoses Research : Book of Abstracts — International Symposium on Zoonoses Research (Hrsg.)

Berlin, 2019 — S. 121

Sprache

Englisch

Verweise

URL (Volltext): https://evis.events/event/79/attachments/23/154/Book_of_Abstracts_Zoonoses2019.pdf

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Clostridioides(previously Clostridium) difficile is a potential pathogen for humans and animals. Human C.difficile infections (CDI)are often healthcare associatedwith varying gastrointestinal tractsymptoms. Nevertheless, one quarter of human CDIis estimated to occur within the community, whereby the source of infection remains unknown. A high overlap of strains occurring in humans and various animal species suggests a possible zoonotic transmission.
During Nov 2017 and Mar 2019, 48 faecal (n=13) and organ samples (n=35) were collected originating from 25 individuals belonging to 16 different reptile species. All isolatedC. difficile strains will be characterizedby PCR ribotyping and PCR detection of toxin genes A, B, and the binary toxin genes. Additionally, Multilocus VNTR Analysis (MLVA) and antimicrobial susceptibility testing will be performed.C. difficile was isolated from 15 (29%) out of 51 samples originating from 12/25 (48%) tested individuals. Although molecular characterization has not yet been completed, preliminary results revealed toxigenic ribotypes that have already previously been related to livestock, humans or the environment, e.g. ribotypes 002/2, 005, and 049. Clinical and pathological data suggest that C. difficile can be associated with fatal conditions in reptiles.
This is the first survey on C. difficile in various reptile species proving that reptiles may represent a possible source of infection for CDI in humans.