Publikationsdatenbank

Large calcified and osteolytic mass on the distal limb:
what else if not a tumour? (2018)

Art

Poster

Autoren

Bertram, Christof (WE 12)

Hoppe, J. (WE 12)

Burger, M.

Zentek, Jürgen (WE 4)

Gruber, A.D. (WE 12)

Kongress

ESCP/ECVP Meeting 2018

Cluj-Napoca, Romania, 05. – 08.09.2018

Quelle

Verweise

URL (Volltext): https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=9&cad=rja&uact=8&ved=2ahUKEwiIioGf7-vjAhVIiqQKHf-nAhYQFjAIegQIABAC&url=https%3A%2F%2Fwww.ecvpath.org%2Fdownload%2F1048%2F&usg=AOvVaw3T2yVFA_k3USSH4YFccATP

Kontakt

Institut für Tierernährung

Königin-Luise-Str. 49
14195 Berlin
+49 30 838 52256
tierernaehrung@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Introduction:
A tumour-like mass on the left, distal forelimb of a dachshund cross had developed over several months causing progressive lameness. Computed tomography revealed a 3.7 x 3.1 x 2.7 cm, radiodense, osteolytic mass around the fifth metacarpophalangeal joint suggestive of osteosarcoma. Histopathology of the resected digit, however, failed to reveal neoplasia but lesions consistent with calcium pyrophosphate crystal deposition disease (CPDD). Here, we describe characteristics of this rare entity also termed pseudogout and how to differentiate it from relevant differential diagnoses.

Materials and Methods:
Routine histopathology including several special stains and examination under polarised light as well as atomic absorption spectrometry and photometry were performed to characterise the lesion and its chemical nature.

Results:
Grossly, periarticular, multinodular chalky deposits with multifocal invasion of bone were observed. The joint cavity and articular cartilage were unaffected. Histopathology revealed pale brown, rectangular to needle-shaped crystals which were von-Kossa positive and positively birefringent consistent with calcium pyrophosphate dihydrate. Crystal nodules were separated by histiocytic cells and fibrous septa. Chemical analysis of the formalin-fixed and partially decalcified tissue revealed 650 mg/g crude ash, 211 mg/g calcium, 159 mg/g phosphorus and a calcium to phosphorus ratio of 1:0.75. Distinct differences to other crystal deposition diseases are described.

Conclusions:
Albeit CPDD occurs only rarely in dogs, this entity should be considered a valid differential diagnosis to calcinosis circumscripta, articular gout, osteosarcoma, callus formation, inflammatory and other bone disorders. Histological patterns, the distinct shape of the crystals, birefringence and the chemical composition are helpful for differentiation.