Publikationsdatenbank

Borna disease virus 1 Infection in alpacas (Lama pacos):
distribution of viral antigen and inflammatory lesions (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Fürstenau, J. (WE 12)

Richter, M.

Große, Reinhard (WE 18)

Müller, K. E. (WE 18)

Rubbenstroth, D.

Mundhenk, L. (WE 12)

Quelle

Journal of comparative pathology

Bandzählung: 174

Seiten: 171

ISSN: 0021-9975

Sprache

Englisch

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/pii/S0021997519304001

DOI: 10.1016/j.jcpa.2019.10.104

Kontakt

Nutztierklinik

Königsweg 65
14163 Berlin
+49 30 838 62261
klauentierklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Introduction:
Horses, sheep and people can act as accidental dead-end hosts of Borna disease virus 1 (BoDV-1). Over a period of 4 months, four female and six male alpacas (Lama pacos) from the same herd in the state of Brandenburg, Germany, had shown neurological disorders or suffered sudden death and nine of these animals died. This report describes the distribution of inflammatory lesions and BoDV-1 in the accidental host alpaca.

Materials and Methods:
Four male alpacas were systematically analysed to determine the distribution of inflammatory infiltrations. RT-qPCR and immunohistochemistry with antibodies specific for bornavirus nucleoprotein and phosphoprotein were used to detect BoDV-1 in different tissues including central and peripheral nervous tissues, intestine, liver and kidney.

Results:
A perivascular, lymphocytic meningoencephalomyelitis with few neutrophils was the predominant lesion, as described before. In addition, severe lymphocytic hypophysitis of the pars intermedia was diagnosed. BoDV-1 was detected in tissues of the central nervous system and in the optic nerve and retina of all animals analysed. Additionally, the facial nerve, sciatic nerve and nasal mucosa of one animal was positive for BoDV-1.

Discussion:
In addition to the central nervous system, the pars intermedia of the pituitary gland and peripheral nerves are important targets of BoDV-1 in alpacas. Furthermore, the northwestern parts of Brandenburg seem to be a previously uncharted endemic area of Borna disease in Germany.