Publikationsdatenbank

Coronary MR angiography: experimental results with a monomer-stabilized blood pool contrast medium (2002)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Taupitz, Matthias

Schnorr, Jörg

Wagner, Susanne

Abramjuk, Claudia

Pilgrimm, Herbert

Kivelitz, Dietmar

Schink, Tania

Hansel, Jörg

Laub, Gerhard

Hünigen, Hanna

Hamm, Bernd

Quelle

Radiology

Bandzählung: 222

Heftzählung: 1

Seiten: 120 – 6

ISSN: 0033-8419

Sprache

Englisch

Verweise

Pubmed: 11756715

Kontakt

Institut für Veterinär-Anatomie

Koserstr. 20
14195 Berlin
+49 30 838 75784
anatomie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

To evaluate the signal-enhancing characteristics of monomer-coated very small superparamagnetic iron oxide (SPIO) particles used as a blood pool contrast medium for magnetic resonance (MR) angiography in the coronary arteries.

The particles used in this study were coated with citrate as the monomer (VSOP-C91). The particles have a total diameter of 7 nm and show the following relaxivities at 0.47 T: T1, 19 L/mmol. sec(-1); T2, 29 L/mmol. sec(-1). Fifteen cardiac MR examinations were performed at 1.5 T in five pigs. Images were acquired from immediately to 35 minutes (equilibrium phase) after intravenous injection of gadopentetate dimeglumine, gadobenate dimeglumine, and the very small SPIO particles (n = 5 for each substance).

Immediately after administration of gadopentetate dimeglumine, gadobenate dimeglumine, and the very small SPIO particles, respectively, increases in the signal-to-noise ratio in blood were 94%, 103%, and 102% and in myocardium were 83%, 83%, and 29% (P <.05, very small SPIO particles versus the low-molecular-weight gadolinium-based compounds). Differences in the blood-to-myocardium contrast-to-noise ratio and visualization of the coronary arteries and their branches were also significant.

VSOP-C91 significantly improves visualization of the coronary arteries at MR angiography from immediately to 35 minutes after injection.