Publikationsdatenbank

Effect of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Paßlack, Nadine (WE 4)

Kohn, Barbara (WE 20)

Zentek, Jürgen (WE 4)

Quelle

Journal of veterinary internal medicine

Bandzählung: 34

Heftzählung: 2

Seiten: 852 – 856

ISSN: 0891-6640

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15736

DOI: 10.1111/jvim.15736

Pubmed: 32086838

Kontakt

Institut für Tierernährung

Königin-Luise-Str. 49
14195 Berlin
+49 30 838 52256
tierernaehrung@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Dietary protein and amino acid intake and composition can modulate immune function.

Objectives:
To evaluate the effects of high‐protein intake and arginine and ornithine supplementation on feline immune cells.

Animals:
Ten healthy cats.

Methods:
Experimental study. Cats received a high‐protein basal diet as a single daily meal. A crossover design was applied with treatments being basal diet (w/o); basal diet with arginine supplementation (+50, 75, 100% compared to the arginine provision by the basal diet; Arg 1‐3); and basal diet with ornithine supplementation (+100, 150, 200% compared to the arginine provision by the basal diet; Orn 1‐3). Blood samples were collected at the end of each 11‐day treatment period.

Results:
Mitogen‐stimulated proliferative activity of blood leukocytes revealed a quadratic effect for the dietary supplementation of arginine (P = .02) and ornithine (P = .03) (means for ConA‐stimulation: w/o = 6.96; Arg 1 = 9.31; Arg 2 = 11.4; Arg 3 = 8.04; Orn 1 = 15.4; Orn 2 = 9.43; Orn 3 = 9.28; pooled SEM: 0.96). The number (% gated) of phagocytic granulocytes linearly decreased with increasing dietary concentrations of arginine (P = .05) and ornithine (P = .03) (means: w/o = 95.5; Arg 1 = 93.0; Arg 2 = 92.5; Arg 3 = 92.6; Orn 1 = 92.6; Orn 2 = 92.6; Orn 3 = 91.5; pooled SEM = 0.44).

Conclusions and Clinical Importance:
This study could demonstrate immunomodulating properties of dietary arginine and ornithine in cats.