Publikationsdatenbank

Intestinal colonization with extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE) during long distance travel:
a cohort study in a German travel clinic (2016-2017) (2019)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Meurs, Lynn

Lempp, Felix S.

Lippmann, Norman

Trawinski, Henning

Rodloff, Arne C.

Eckardt, Matthias

Klingeberg, Anja

Eckmanns, Tim

Walter, Jan

Lübbert, Christoph

Quelle

Travel medicine and infectious disease

Bandzählung: 33

Seiten: Article 101521

ISSN: 1873-0442

Sprache

Englisch

Verweise

URL (Volltext): https://www.sciencedirect.com/science/article/pii/S1477893919302248

DOI: 10.1016/j.tmaid.2019.101521

Pubmed: 31770602

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Intercontinental travel contributes to the spread of extended-spectrum beta-lactamase producing Enterobacterales (ESBL-PE). We assessed risk factors for intestinal ESBL-PE colonization in people travelling to low and middle income countries in the tropics and subtropics to better understand how travel affects ESBL-PE spread.

Method:
This prospective cohort study in travellers attending a travel clinic in Leipzig, Germany was conducted in 2016-2017. Information on risk factors related to travel, symptoms, antibiotic use, health care usage, accommodation, destination, diet and hygiene was collected by questionnaire after travel. Stools were phenotypically tested for ESBL-PE before and after travel. Risk factors for ESBL-PE colonization were identified using logistic regression.

Results:
Of the 230 travellers that were ESBL-PE negative before travelling, 23% (n = 53) travellers returned positive. Multivariable analyses showed that age, type of accommodation and travelling to Asia were associated with ESBL-PE colonization.

Conclusion:
Given that a considerable amount of travellers returned with ESBL-PE, we recommend raising awareness in returning high-risk travellers, e.g. those returning from high-risk areas. They should be aware that they may carry antimicrobial-resistant bacteria after travel, and how they can prevent its spread. The role of the type of accommodation as a factor favouring intestinal colonization with ESBL-PE requires further investigation.

Teilnehmer der Rai Study group: u.a. Prof. Dr. Lothar H. Wieler und Dr. Antina Lübke-Becker aus dem Institut für Mikrobiologie und Tierseuchen (WE07)