Publikationsdatenbank

Efficacy of imidacloprid 10%/moxidectin 1% spot-on formulation (Advocate®) in the prevention and treatment of feline aelurostrongylosis (2020)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Heuer, Lea

Petry, Gabriele

Pollmeier, Matthias

Schaper, Roland

Deuster, Katrin

Schmidt, Holger

Blazejak, Katrin

Strube, Christina

Di Cesare, Angela

Traversa, Donato

Schnyder, Manuela

McKay-Demeler, Janina (WE 13)

von Samson-Himmelstjerna, Georg (WE 13)

Mangold-Gehring, Sandra

Böhm, Claudia

Quelle

Parasites & vectors

Bandzählung: 13

Seiten: Article number: 65

ISSN: 1756-3305

Sprache

Englisch

Verweise

URL (Volltext): https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-020-3937-2

DOI: 10.1186/s13071-020-3937-2

Pubmed: 32051008

Kontakt

Institut für Parasitologie und Tropenveterinärmedizin

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 62310
parasitologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
In three randomized, controlled laboratory efficacy studies, the efficacy in the prevention of patent infections of a topical combination of imidacloprid 10%/moxidectin 1% (Advocate® spot-on formulation for cats, Bayer Animal Health GmbH) against larval stages and immature adults of Aelurostrongylus abstrusus, as well as the treatment efficacy of a single or three monthly treatments against adult A. abstrusus, were evaluated.

Methods:
Cats were experimentally inoculated with 300-800 third-stage larvae (L3). Each group comprised 8 animals and the treatment dose was 10 mg/kg bodyweight (bw) imidacloprid and 1 mg/kg bw moxidectin in each study. Prevention of the establishment of patent infections was evaluated by two treatments at a monthly interval at three different time points before and after challenge infection. Curative efficacy was tested by one or three treatments after the onset of patency. Worm counts at necropsy were used for efficacy calculations.

Results:
In Study 1, the control group had a geometric mean (GM) of 28.8 adult nematodes and the single treatment group had a GM of 3.4 (efficacy 88.3%). In Study 2, the control group had a GM of 14.3, the prevention group had a GM of 0 (efficacy 100%), while the treatment group had a GM of 0.1 (efficacy 99.4%). In Study 3, the GM worm burden in the control group was 32.6 compared to 0 in all three prevention groups (efficacy 100% for all of those groups).

Conclusions:
The monthly administration of Advocate® reliably eliminated early larval stages and thereby prevented lung damage from and patent infections with A. abstrusus in cats. Regarding treatment, a single application of Advocate® reduced the worm burden, but it did not sufficiently clear the infection. In contrast, three monthly treatments were safe and highly efficacious against A. abstrusus.