Publikationsdatenbank

Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals (2019)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Li, Jiyun

Bi, Zhenwang

Ma, Shizhen

Chen, Baoli

Cai, Chang

He, Junjia

Schwarz, Stefan (WE 7)

Sun, Chengtao

Zhou, Yuqing

Yin, Jia

Hulth, Anette

Wang, Yongqiang

Shen, Zhangqi

Wang, Shaolin

Wu, Congming

Nilsson, Lennart E

Walsh, Timothy R

Börjesson, Stefan

Shen, Jianzhong

Sun, Qiang

Wang, Yang

Quelle

Environmental health perspectives

Bandzählung: 127

Heftzählung: 10

Seiten: Article 107009

ISSN: 1552-9924

Sprache

Englisch

Verweise

URL (Volltext): https://ehp.niehs.nih.gov/doi/10.1289/EHP5251

DOI: 10.1289/EHP5251

Pubmed: 31642700

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

BACKGROUND: The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied.

OBJECTIVES: We investigated the prevalence, risk factors, and drivers of CRE transmission between humans and their backyard animals in rural China.

METHODS: We conducted a comprehensive sampling strategy in 12 villages in Shandong, China. Using the household [residents and their backyard animals (farm and companion animals)] as a single surveillance unit, we assessed the prevalence of CRE at the household level and examined the factors associated with CRE carriage through a detailed questionnaire. Genetic relationships among human- and animal-derived CRE were assessed using whole-genome sequencing-based molecular methods.

RESULTS: A total of 88 New Delhi metallo-β-lactamases-type carbapenem-resistant Escherichia coli (NDM-EC), including 17 from humans, 44 from pigs, 12 from chickens, 1 from cattle, and 2 from dogs, were isolated from 65 of the 746 households examined. The remaining 12 NDM-EC were from flies in the immediate backyard environment. The NDM-EC colonization in households was significantly associated with a) the number of species of backyard animals raised/kept in the same household, and b) the use of human and/or animal feces as fertilizer. Discriminant analysis of principal components (DAPC) revealed that a large proportion of the core genomes of the NDM-EC belonged to strains from hosts other than their own, and several human isolates shared closely related core single-nucleotide polymorphisms and bla_NDM genetic contexts with isolates from backyard animals.

CONCLUSIONS: To our knowledge, we are the first to report evidence of direct transmission of NDM-EC between humans and animals. Given the rise of NDM-EC in community and hospital infections, combating NDM-EC transmission in backyard farm systems is needed.