Publikationsdatenbank

RORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection (2019)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Yordanova, Ivet A (WE 6)

Cortés, Alba

Klotz, Christian

Kühl, Anja A

Heimesaat, Markus M

Cantacessi, Cinzia

Hartmann, Susanne (WE 6)

Rausch, Sebastian (WE 6)

Quelle

Scientific reports

Bandzählung: 9

Heftzählung: 1

Seiten: Article number 20328

ISSN: 2045-2322

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41598-019-56416-9

DOI: 10.1038/s41598-019-56416-9

Pubmed: 31889073

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with varying susceptibility to Giardia muris infection. Infected BALB/c mice shed significantly more cysts compared with C57BL/6 mice. Impaired control of infection in BALB/c mice was associated with lower Th17 activity and lower IgA levels compared with C57BL/6 mice. The limited metabolic activity, proliferation and cytokine production of Th17 cells in BALB/c mice was associated with higher proportions of intestinal Foxp3+RORγt+ regulatory T cells and BALB/c mice developed increased RORγt+ Treg:Th17 ratios in response to G. muris infection. Furthermore, G. muris colonization led to a significantly reduced evenness in the gut microbial communities of BALB/c mice. Our data indicate that differential susceptibility to Giardia infections may be related to RORγt+ Treg controlling Th17 activity and that changes in the microbiota composition upon Giardia infection partially depend on the host background.