Publikationsdatenbank

Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Partridge, Sally R

Di Pilato, Vincenzo

Doi, Yohei

Feldgarden, Michael

Haft, Daniel H

Klimke, William

Kumar-Singh, Samir

Liu, Jian-Hua

Malhotra-Kumar, Surbhi

Prasad, Arjun

Rossolini, Gian Maria

Schwarz, Stefan (WE 7)

Shen, Jianzhong

Walsh, Timothy

Wang, Yang

Xavier, Basil Britto

Quelle

The journal of antimicrobial chemotherapy : JAC

Bandzählung: 73

Heftzählung: 10

Seiten: 2625 – 2630

ISSN: 0305-7453

Sprache

Englisch

Verweise

DOI: 10.1093/jac/dky262

Pubmed: 30053115

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The initial report of the mcr-1 (mobile colistin resistance) gene has led to many reports of mcr-1 variants and other mcr genes from different bacterial species originating from human, animal and environmental samples in different geographical locations. Resistance gene nomenclature is complex and unfortunately problems such as different names being used for the same gene/protein or the same name being used for different genes/proteins are not uncommon. Registries exist for some families, such as bla (β-lactamase) genes, but there is as yet no agreed nomenclature scheme for mcr genes. The National Center for Biotechnology Information (NCBI) recently took over assigning bla allele numbers from the longstanding Lahey β-lactamase website and has agreed to do the same for mcr genes. Here, we propose a nomenclature scheme that we hope will be acceptable to researchers in this area and that will reduce future confusion.