Publikationsdatenbank

Carbapenem-resistant Enterobacteriaceae in wildlife, food-producing, and companion animals: a systematic review (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Köck, R

Daniels-Haardt, I

Becker, K

Mellmann, A

Friedrich, A W

Mevius, D

Schwarz, S (WE 7)

Jurke, A

Quelle

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases ; CMI

Bandzählung: 24

Heftzählung: 12

Seiten: 1241 – 1250

ISSN: 1470-9465

Sprache

Englisch

Verweise

DOI: 10.1016/j.cmi.2018.04.004

Pubmed: 29654871

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The spread of carbapenem-resistant Enterobacteriaceae (CRE) in healthcare settings challenges clinicians worldwide. However, little is known about dissemination of CRE in livestock, food, and companion animals and potential transmission to humans.

We performed a systematic review of all studies published in the PubMed database between 1980 and 2017 and included those reporting the occurrence of CRE in samples from food-producing and companion animals, wildlife, and exposed humans. The primary outcome was the occurrence of CRE in samples from these animals; secondary outcomes included the prevalence of CRE, carbapenemase types, CRE genotypes, and antimicrobial susceptibilities.

We identified 68 articles describing CRE among pigs, poultry, cattle, seafood, dogs, cats, horses, pet birds, swallows, wild boars, wild stork, gulls, and black kites in Africa, America, Asia, Australia, and Europe. The following carbapenemases have been detected (predominantly affecting the genera Escherichia and Klebsiella): VIM, KPC, NDM, OXA, and IMP. Two studies found that 33-67% of exposed humans on poultry farms carried carbapenemase-producing CRE closely related to isolates from the farm environment. Twenty-seven studies selectively screened samples for CRE and found a prevalence of <1% among livestock and companion animals in Europe, 2-26% in Africa, and 1-15% in Asia. Wildlife (gulls) in Australia and Europe carried CRE in 16-19%.

The occurrence of CRE in livestock, seafood, wildlife, pets, and directly exposed humans poses a risk for public health. Prospective prevalence studies using molecular and cultural microbiological methods are needed to better define the scope and transmission of CRE.